Recommendations for Epstein-Barr virus-based screening for nasopharyngeal cancer in high- and intermediate-risk regions
Journal
Journal of the National Cancer Institute
Journal Volume
115
Journal Issue
4
Date Issued
2023-04-11
Author(s)
Lam, W K Jacky
King, Ann D
Miller, Jacob A
Liu, Zhiwei
Yu, Kelly J
Chua, Melvin L K
Ma, Brigette B Y
Chen, Ming Yuan
Pinsky, Benjamin A
Woo, John K S
Hsu, Wan-Lun
Simon, Julia
Doolan, Denise L
Waterboer, Tim
Hui, Edwin P
Li, Hui
Tsang, Raymond K
Wong, Kenneth C W
Goh, Julian P
Vlantis, Alexander C
Ai, Qi Yong
Wong, Lun M
Abdullah, Victor
Lin, Jin Ching
Chen, Chien-Jen
Pfeiffer, Ruth M
Le, Quynh-Thu
Lee, Anne W M
Ji, Mingfang
Cao, Sumei
Ma, Jun
Chan, Anthony T C
Chan, K C Allen
Hildesheim, Allan
Abstract
A meeting of experts was held in November 2021 to review and discuss available data on performance of Epstein-Barr virus (EBV)-based approaches to screen for early stage nasopharyngeal carcinoma (NPC) and methods for the investigation and management of screen-positive individuals. Serum EBV antibody and plasma EBV DNA testing methods were considered. Both approaches were found to have favorable performance characteristics and to be cost-effective in high-risk populations. In addition to endoscopy, use of magnetic resonance imaging (MRI) to investigate screen-positive individuals was found to increase the sensitivity of NPC detection with minimal impact on cost-effectiveness of the screening program.
SDGs
Type
journal article