Synthesis and bioactivity of novel phthalimide derivatives
Journal
Chinese Chemical Letters
Journal Volume
19
Journal Issue
1
Pages
26-28
Date Issued
2008
Author(s)
Abstract
Novel phthalimide derivatives (4a, 4b and 6a-6e) were designed as hybrids of thalidomide and NO-ASA, and their chemical synthesis and in vitro biological activities were presented. The preliminary results showed that compared to thalidomide 4a and 4b exhibited enhanced activities against ECV304 and HepG2 cells, whereas 6c was more potent against HepG2 cells. © 2007 Yi Hua Zhang.
Type
journal article