Anti-inflammatory activity of traditional chinese medicinal herbs
Journal
Journal of Traditional and Complementary Medicine
Journal Volume
1
Journal Issue
1
Pages
8-24
Date Issued
2011
Author(s)
Abstract
Accumulating epidemiological and clinical evidence shows that inflammation is an important risk factor for various human diseases. Thus, suppressing chronic inflammation has the potential to delay, prevent, and control various chronic diseases, including cerebrovascular, cardiovascular, joint, skin, pulmonary, blood, lymph, liver, pancreatic, and intestinal diseases. Various natural products from traditional Chinese medicine (TCM) have been shown to safely suppress proinflammatory pathways and control inflammation-associated disease. In vivo and/or in vitro studies have demonstrated that anti-inflammatory effects of TCM occur by inhibition of the expression of master transcription factors (for example, nuclear factor-κB (NF-κB)), pro-inflammatory cytokines (for example, tumor necrosis factor- (TNF-), chemokines (for example, chemokine (C-C motif) ligand (CCL)-24), intercellular adhesion molecule expression and pro-inflammatory mediators (for example, inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (COX2)). However, a handful of review articles have focused on the anti-inflammatory activities of TCM and explore their possible mechanisms of action. In this review, we summarize recent research attempting to identify the anti-inflammatory constituents of TCM and their molecular targets that may create new opportunities for innovation in modern pharmacology. Copyright © 2011 Committee on Chinese Medicine and Pharmacy, Taiwan.
SDGs
Type
journal article
File(s)![Thumbnail Image]()
Loading...
Name
1-s2.0-S2225411016300529-main.pdf
Size
6.27 MB
Format
Adobe PDF
Checksum
(MD5):aab663eff66bb24661a3ceb768d333c0