Angiotensin receptor blockers and β blockers in Marfan syndrome: an individual patient data meta-analysis of randomised trials
Journal
Lancet (London, England)
Journal Volume
400
Journal Issue
10355
Date Issued
2022-09-10
Author(s)
Pitcher, Alex
Spata, Enti
Emberson, Jonathan
Davies, Kelly
Halls, Heather
Holland, Lisa
Wilson, Kate
Reith, Christina
Child, Anne H
Clayton, Tim
Dodd, Matthew
Flather, Marcus
Jin, Xu Yu
Sandor, George
Groenink, Maarten
Mulder, Barbara
De Backer, Julie
Evangelista, Arturo
Forteza, Alberto
Teixido-Turà, Gisela
Boileau, Catherine
Jondeau, Guillaume
Milleron, Olivier
Lacro, Ronald V
Sleeper, Lynn A
Chiu, Hsin-Hui
Neubauer, Stefan
Watkins, Hugh
Dietz, Hal
Baigent, Colin
Abstract
Angiotensin receptor blockers (ARBs) and β blockers are widely used in the treatment of Marfan syndrome to try to reduce the rate of progressive aortic root enlargement characteristic of this condition, but their separate and joint effects are uncertain. We aimed to determine these effects in a collaborative individual patient data meta-analysis of randomised trials of these treatments.
Type
journal article