The anti-cancer effect of BMVC, a G-quadruplex binding compound
Date Issued
2005
Date
2005
Author(s)
Back, Hong-Tsun
DOI
zh-TW
Abstract
Compare to normal somatic cells, more than 85% of cancer cells have higher telomerase activity to maintain their length of telomere. Therefore, inhibiting the function of telomerase is a considerable way to interfere cancer proliferation. BMVC was designed for interacting with G-quadruplex, a DNA four strand structure that is abounded with Guanine nucleotides, especially the sequence of human telomere [5’-（TTAGGG）n-3’]. Based on acute cytotoxicity assay, BMVC has higher cytotoxicity on cancer cells, which 50% lethal dose is about 10 μM. According to telomeric repeat amplification protocol assay, BMVC is a potent telomerase inhibitor with 50% inhibition concentration at 0.25 μM. Under confocal microscopy observation, BMVC enter the nucleus which might further affect cellular function. Cell culture and animal study show that proliferation ability of cancer cells may inhibited under nonacute cytotoxic concentration of BMVC treatment.
Subjects
鳥糞嘌呤四股結構
G-quadruplex binding compound
SDGs
Type
other