PEDF-derived peptide promotes tendon regeneration through its mitogenic effect on tendon stem/progenitor cells
Journal
Stem cell research & therapy
Journal Volume
10
Journal Issue
1
Date Issued
2019-01-03
Author(s)
Ho, Tsung-Chuan
Tsai, Shawn H
Yeh, Shu-I
Tung, Kwang-Yi
Chien, Hsin-Yu
Lu, Yung-Chang
Huang, Chang-Hung
Tsao, Yeou-Ping
Abstract
Tendon stem/progenitor cells (TSPC) exhibit a low proliferative response to heal tendon injury, leading to limited regeneration outcomes. Exogenous growth factors that activate TSPC proliferation have emerged as a promising approach for treatment. Here, we evaluated the pigment epithelial-derived factor (PEDF)-derived short peptide (PSP; 29-mer) for treating acute tendon injury and to determine the timing and anatomical features of CD146- and necleostemin-positive TSPC in the tendon healing process.
Subjects
PEDF; Peptide; Signaling; Tendon stem/progenitor cell
SDGs
Other Subjects
alginic acid; broxuridine; CD146 antigen; cell protein; collagen type 1; collagen type 3; growth factor; mitogen activated protein kinase 1; nestin; nucleostemin; octamer transcription factor 4; pigment epithelium derived factor derived short peptide; STAT3 protein; unclassified drug; eye protein; nerve growth factor; peptide; pigment epithelium-derived factor; serine proteinase inhibitor; achilles tendon rupture; adult; animal cell; animal experiment; animal model; animal tissue; Article; biomechanics; cell differentiation; cell infiltration; cell proliferation; cell stimulation; cellular distribution; clonogenesis; collagen fiber; colony formation; controlled study; drug efficacy; healing; immunohistochemistry; male; mitogenesis; New Zealand White (rabbit); nonhuman; priority journal; protein analysis; protein expression; protein phosphorylation; rat; stem cell; stem cell expansion; stem cell niche; sustained drug release; tendon healing; tendon stem cell; tenocyte; tensile strength; tissue regeneration; Western blotting; wound healing; achilles tendon; animal; cytology; genetics; human; Leporidae; metabolism; pathophysiology; regeneration; stem cell; tendon injury; Achilles Tendon; Animals; Eye Proteins; Humans; Nerve Growth Factors; Peptides; Rabbits; Rats; Regeneration; Serpins; Stem Cells; Tendon Injuries
Publisher
BMC
Type
journal article