光動力療法合併高溫腫瘤治療對於大腸癌細胞之影響
Date Issued
2003-07-31
Date
2003-07-31
Author(s)
王正一
DOI
912213E002118
Abstract
Recently, malignancy is the leading cause of mortality in Taiwan, and colon cancer
accounted approximately 4000 deaths each year. Photodynamic therapy (PDT) is a promising
new treatment for cancer that has been recently accepted in the clinic. PDT involves the
localization of a light-sensitive drug in the target tissue prior to illumination using an appropriate
wavelength. Exposure of tissue containing a sufficient concentration of photosensitizer to
irradiation of adequate wavelengths initiates photodynamic activation to generate single oxygen
free radicals and other reactive species, causing cellular damage and tissue necrosis. It is a
procedure having the potential to selectively destroy malignant tissues without causing serious
damage to the adjacent normal structures if light dosimetry can be delivered with care.
This study relates to studies on modes of phtotoxicity after incubation of 5-aminolevulinic
acid (5-ALA) on colon cancer cells and compared with hyperthermia treated. The viability
results show that the survivals of the colon cancer cells were decreased after PDT or
hyperthermia alone as incubation time increased. The Annexin V-FITC/PI assay shows that the
cells were apoptosis after PDT or hyperthermia treatment alone. Although PDT and hyperthermia
both cause cell apoptosis, the mechanism are different. How to combine these two treatments and
the sequence are need to study more.
Subjects
photodynamic therapy
hyperthermia
colon cancer cells
SDGs
Publisher
臺北市：國立臺灣大學醫學工程學研究所
Type
report
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