Gadolinium(III)-incorporated nanosized mesoporous silica as potential magnetic resonance imaging contrast agents
Journal
Journal of Physical Chemistry B
Journal Volume
108
Journal Issue
40
Pages
15608-15611
Date Issued
2004
Author(s)
Abstract
A new class of potential magnetic resonance imaging contrast agents with nanosized mesoporous silica as the metal carrier is reported. Gadolinium-incorporated mesoporous silicas were synthesized by using long-chain surfactant as a template. The products were characterized with X-ray powder diffraction, nitrogen adsorption−desorption isotherms, high-resolution transmission electron microscopy, X-ray photoelectron spectroscopy, 29Si-MAS NMR, and proton relaxivity. The materials showed much higher relaxivities, r1 and r2, than Gd-DTPA. The particles are nanosized and can enter cells easily. This is a completely novel biomedical application of mesoporous silica materials.
Type
journal article