Role of virulence plasmid p32kb with citA or citABC in severe invasive infections of community-associated methicillin-resistant Staphylococcus aureus ST8/SCCmecIVl.
Journal
Journal of Microbiology Immunology and Infection
ISSN
1995-9133
Date Issued
2025-11-04
Author(s)
Wan, Tsai-Wen
Tomita, Yusuke
Sawanobori, Emi
Ishitobi, Natsuko
Kojima, Kenji K
Matsumoto, Tetsuya
Takemura, Hiromu
Shintani, Masaki
Hung, Wei-Chun
Wang, Yu-Ting
Yamamoto, Tatsuo
Abstract
Community-associated methicillin-resistant Staphylococcus aureus ST8/SCCmecIVl occasionally causes invasive infections. Only severe cases harbored p32kb, with repA1, oriT-based recombination with conjugative pWtra, and a virulence gene cluster with varying citABC positivity associated with intramuscular and non-intramuscular infections. Our findings highlight the potentially critical role of citA (CitA superantigen), which may be applied as a potential severity marker.
Subjects
Community-associated methicillin-resistant Staphylococcus aureus
Mutation
Severe invasive infection
Superantigen gene (citA)
Virulence plasmid
Publisher
Elsevier Ltd
Type
journal article