Effects of teriparatide on lung function and pain relief in women with multiple osteoporotic vertebral compression fractures
Journal
Surgical Neurology International
Journal Volume
5
Journal Issue
7Supplement
Pages
S339-S342
Date Issued
2014
Author(s)
Chen C.-M.
Lin P.-Y.
Chen Y.-C.
Jin Y.
Lin S.-H.
Hsing M.-T.
Cheng Y.-P.
Cheng C.-Y.
Abstract
Background: Osteoporosis is predominantly a condition of the elderly. In this study, we evaluated the effects of teriparatide on lung function and pain relief in elderly women with multiple osteoporotic vertebral compression fractures. Methods: A total of 37 patients who received teriparatide treatment during the period January 2010 to December 2011 were enrolled. Dual-energy X-ray absorptiometry scans were used to measure bone mineral density (BMD) and lung function was measured using a MasterScreen Body Jaeger spirometer. Forced expiratory volume in 1 s (FEV 1 ) and forced vital capacity (FVC) values were recorded. The Oswestry Disability Index (ODI) and the Visual Analog Scale (VAS) for pain were used to evaluate physical health and pain intensity, respectively, at baseline and after 6 months of teriparatide treatment. Results: Mean BMD at the lumbar spine increased from 0.716 g/cm 2 at baseline to 0.829 g/cm 2 after 6 months of treatment. In addition, both mean FVC and FEV 1 values after 6 months of treatment were significantly higher than baseline values (99.01% and 100.06% vs. 87.62% and 90.62%, respectively). Teriparatide treatment also resulted in a significant reduction in self-reported pain intensity and a significant improvement in physical health as measured by VAS and ODI scores, respectively. Conclusions: In addition to increasing BMD, teriparatide treatment improves the lung function and results in diminished pain intensity in women with multiple osteoporotic vertebral compression fractures.
SDGs
Other Subjects
calcium carbonate; parathyroid hormone[1-34]; vitamin D; aged; analgesia; Article; backache; bone density; clinical article; compression fracture; drug effect; female; forced expiratory volume; forced vital capacity; fragility fracture; human; lung function; Oswestry Disability Index; pain intensity; prospective study; treatment outcome; visual analog scale; clinical evaluation; compression fracture; dual energy X ray absorptiometry; health status; osteoporosis; pain assessment; priority journal; self report; spine fracture; spirometry; treatment duration
Publisher
Medknow Publications
Type
journal article