Diterpenoids, norditerpenoids, and secosteroids from the formosan soft coral Cespitularia hypotentaculata
Journal
Journal of Natural Products
Journal Volume
69
Journal Issue
8
Pages
1188-1192
Date Issued
2006
Author(s)
Abstract
Four new cespitularane diterpenes, cesputularins I-L (1-4), two new norverticillane norditerpenes, cespitularins M and N (5 and 6), two new verticillane diterpenes, cespitularins O and P (7 and 8), a new norditerpene, cespitularin Q (9) (having a novel carbon skeleton), a new xenicane diterpene, cespitolide (10), and two new secosteroids, 3β,11-dihydroxy-5β, 6β-epoxy-9,11-secocholestan-9-one (11) and 3β,11-dihydroxy-5β, 6β-epoxy-9,11-secogorgostan-9-one (12), were isolated from the methylene chloride solubles of the Formosan soft coral Cespitularia hypotentaculata Roxas. The structures were elucidated by extensive spectroscopic analysis, and their cytotoxicity against selected cancer cells was measured in vitro. ? 2006 American Chemical Society and American Society of Pharmacognosy.
Other Subjects
3beta,11 dihydroxy 5beta,6beta epoxy 9,11 secocholestan 9 one; 3beta,11 hydroxy 5beta,6beta epoxy 9,11 secogorgostan 9 one; cespitolide; Cespitularia hypotentaculata extract; cespitularin i; cespitularin j; cespitularin k; cespitularin l; cespitularin m; cespitularin n; cespitularin o; cespitularin p; cespitularin q; dichloromethane; diterpenoid; natural product; norditerpenoid derivative; secosteroid; unclassified drug; article; carbon nuclear magnetic resonance; chemical structure; controlled study; coral; nonhuman; proton nuclear magnetic resonance; Animals; Anthozoa; Antineoplastic Agents; Computer Simulation; Diterpenes; Drug Screening Assays, Antitumor; Leukemia P388; Mice; Molecular Conformation; Molecular Structure; Secosteroids; Taiwan; Tumor Cells, Cultured; Alcyonacea
Type
journal article