The effect of mesalazine (5-ASA) enemas in patients with mild to moderate proctitis or proctosigmoiditis - A preliminary report in Taiwan
Journal
Biomedical Engineering - Applications, Basis and Communications
Journal Volume
11
Journal Issue
5
Pages
285-288
Date Issued
1999
Author(s)
Abstract
We conducted a clinical trial at a referral center (National Taiwan University Hospital) to evaluate the efficacy and safety of mesalazine (5-ASA) enemas in fourteen Taiwanese patients with relapse of distal ulcerative colitis (UC). Clinical, endoscopic and histological assessments were done at entry and every four weeks. Our results showed that short-term therapy with nightly 5-ASA enemas induced prompt remission in a majority of patients previously unresponsive to conventional therapy. Side effects were few and insignificant. No significant changes were observed in hematology, blood chemistry, or urinalysis. None was withdrawn from the study following initial selection for this trial. Our preliminary results indicated that 5-ASA enemas are an effective, well-tolerated medication for the treatment of UC confined to the distal colon.
Subjects
Distal ulcerative colitis; Mesalazine (5-ASA) enema
SDGs
Other Subjects
enema; mesalazine; adult; article; clinical article; clinical trial; drug efficacy; drug induced disease; drug safety; drug tolerability; female; human; male; proctitis; relapse; remission; Taiwan; ulcerative colitis; Blood; Diseases; Endoscopy; Enemas; Patient treatment
Type
journal article