The glycine allele of a glycine/arginine polymorphism in the β2-adrenergic receptor gene is associated with essential hypertension in a population of Chinese origin
Journal
American Journal of Hypertension
Journal Volume
14
Journal Issue
12
Pages
1196-1200
Date Issued
2001
Author(s)
Ranade K.
Shue W.H.-H.
Hung Y.-J.
Hsuing C.A.
Pesich R.
Hebert J.
Olivier M.
Chen Y.-D.I.
Pratt R.
Olshen R.
Curb D.
Botstein D.
Risch N.
Cox D.R.
Abstract
Background: Several studies implicate polymorphisms in the human β2-adrenergic receptor gene (ADRB2) in the susceptibility to hypertension. We sought to replicate these results in a population of Chinese origin primarily from Taiwan and the San Francisco Bay area. Methods: We genotyped >800 hypertensive subjects and individuals with low-normal blood pressure that were derived largely from the same families as the hypertensive patients for three polymorphisms in the ADRB2 gene: a C/T transition at position 47 (C-47T) in the 5′ leader cistron; another C/T transition that results in a glycine/arginine substitution at codon 16 (Gly16Arg), and a G/C transversion that causes a glutamate/glutamine substitution at codon 27 (Glu27Gln). Results: The Gly16Arg was significantly associated with hypertension (P < .03). Under a dominant model, for hypertension the relative risk for the Gly/Gly and Gly/Arg genotypes versus the Arg/Arg genotype was 1.35 (95% confidence limits [CL] 1.08, 1.70); for low-normal blood pressure the relative risk was 0.79 (95% CL 0.66, 0.94). This polymorphism explained approximately 1% of the variance in systolic and diastolic blood pressures in our study population. There was no evidence of association between the C-47T and Glu27Gln polymorphisms and hypertension in this population. Conclusions: The Gly16 allele in the β2-adrenergic receptor gene is a susceptibility allele for essential hypertension in a population of Chinese origin. ? 2001 American Journal of Hypertension, Ltd.
Subjects
β2-adrenergic receptor; Association; Blood pressure variation; Hypertension; Polymorphism
SDGs
Other Subjects
arginine; beta 2 adrenergic receptor; cytidine; glutamic acid; glutamine; glycine; guanosine; thymidine; adult; allele; amino acid substitution; article; Chinese; cistron; codon; diastolic blood pressure; essential hypertension; female; genetic model; genetic risk; genetic susceptibility; genotype; human; major clinical study; male; priority journal; risk factor; single nucleotide polymorphism; systolic blood pressure; Taiwan; United States; Arginine; Asian Continental Ancestry Group; Blood Pressure; Family Health; Female; Genotype; Glycine; Humans; Hypertension; Male; Middle Aged; Polymorphism, Single Nucleotide; Receptors, Adrenergic, beta-2
Type
journal article