Sirtuin 6 ameliorates arthritis through modulating cyclic AMP-responsive element binding protein/CCN1/cyclooxygenase 2 pathway in osteoblasts
Journal
Journal of bone and mineral metabolism
Date Issued
2023-10-29
Author(s)
Yang, Cheng-Ning
Hong, Chi-Yuan
Chen, Mu-Hsiung
EDDIE HSIANG HUA LAI
Wu, Fang-Yu
Abstract
CCN1 is an immediate-early gene product pivotal for arthritis progression. We have previously shown that sirtuin 6 (SIRT6) inhibited hypoxia-induced CCN1 expression in osteoblasts. Herein we examined the contribution of cyclic AMP-responsive element binding protein (CREB)/CRE to this suppressive action and the influence of CCN1 on cyclooxygenase (COX) 2 synthesis.
Subjects
CCN1; Collagen-induced arthritis; Cyclic AMP-responsive element binding protein; Cyclooxygenase 2; Sirtuin 6
SDGs
Type
journal article