1,8-萘啶衍生物在鳥糞嘌呤核苷單磷酸感測分子之設計及合成
Design and Synthesis of GMP Chemosensors by Using Naphthyridine Derivatives
Date Issued
2004
Date
2004
Author(s)
Chen, Ching-Wen
DOI
zh-TW
Abstract
GMP recognition is a very important subject in bioorganic chemistry research, because GMP plays a crucial role in message transmission and c DNA (RNA) formation. Recognition of GMP can be used in diagnosis of diseases.
This thesis presents the design and synthesis of nitrogen-containing compounds as the hydrogen-bonding receptors for biologically important GMP substrate.
We have synthesized several receptors including ANYA, NAEON and NAEN; which consist of amino-substituted naphthyridine moieties for interactions with GMP via multiple hydrogen-bondings. We used fluorescence, UV-Vis absorption spectrum, and NMR spectra to study their interaction modes.
Subjects
萘
啶
GMP
Naphthyridine
Type
thesis
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