ASSOCIATION BETWEEN SEROPOSITIVITY OF ANTIBODIES AGAINST HEPATITIS A VIRUS AND HELICOBACTER PYLORI
Resource
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE v.63 n.3-4 pp.189-191
Journal
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
Journal Volume
v.63
Journal Issue
n.3-4
Pages
189-191
Date Issued
2000
Date
2000
Author(s)
LIN, DING-BANG
TSAI, TSUNG-PO
YANG, CHI-CHIANG
YOU, SAN-LIN
HO, MEI-SHANG
CHEN, CHIEN-JEN
Abstract
Helicobacter Pylori and hepatitis A virus (HAV) are
documented to share common transmission routes including
fecal-oral. This study examined the association between
seropositivity of antibodies against H. pylori (anti-HP) and
HAV (anti-HAV) via a community-based survey of 40 randomly
selected kindergartens in 10 urban and 10 rural areas. Serum
samples from 2,047 healthy preschool children and 104
teachers were screened for anti-HP by enzyme-linked
immunosorbent assay, and for anti-HAV by microparticle
enzyme immunoassay. In children, a low prevalence of anti-
HAV (0.44%) was found, in contrast to a high prevalence in
their teachers (78.8%); anti-HP seroprevalence was 6.4% for
children and 30.8% for teachers. Anti-HAV and anti-HP
seropositivities were significantly associated in teachers
after adjustment for age, sex, and residential area through
multiple logistic regression analysis (multivariate-adjusted
odds ratio = 7.3, 95% confidence interval [CI] = 1.4-36.8,
P < 0.001). Our findings suggest that HAV and H. pylori may
have shared transmission routes in central Taiwan 15 years
or more ago, but not any recently.
Subjects
A VIRUS
INFECTION
TRANSMISSION
SEROPREVALENCE
SEROEPIDEMIOLOGY
TAIWAN
SDGs
Type
journal article