行政院國家科學委員會專題研究計畫成果報告:苗勒氏肌在甲狀腺上眼瞼攣縮致病機轉的角色
Date Issued
2005
Date
2005
Author(s)
廖述朗
DOI
932314B002092
Abstract
Purpose: Among the clinical manifestations, upper lid retraction is the most common
ocular sign of Graves’ ophthalmology (GO). Although several mechanisms have been
postulated, the exact pathology of Müller’s muscle in pathogenesis of upper lid
retraction is not fully elucidated. To study the relation between tissue pathology and
the severity of upper lid retraction, we have created an innovative methodology to
quantify the pathological changes.
Methods & Materials: Twenty GO Müller’s muscles were consecutively collected,
and the severity of upper lid retraction measured by MRD1 was also recorded. The
excised Müller’s muscle was fixed in formalin and sectioned in 3-µ m thickness,
which was stained serially with H&E, Toluidine blue, Masson’s trichrome stain, and
several immunohistochemistries including LCA, CD3, CD20, CD68, HLA-DR,
caspase 3, and TSHr.
Results & Conclusion: We showed that the degree of fibrosis in the diseased Mü ller's
muscle correlated with the severity of upper lid retraction especially in patients with
severe GO. In addition, normal muscle volume was decreased and replaced by fat and
fibrosis infiltration. However, there was no evidence of apoptosis in Müller's muscle.
On the other hand, the number of macrophages increased in most of diseased Mü ller's
muscles with predominant fibrotic changes, providing a role for macrophage during
fibrogenesis.
Publisher
臺北市：國立臺灣大學醫學院眼科
Type
journal article
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