Platelet count/spleen diameter ratio in the differentiation of alcoholic liver disease from alcoholic liver disease plus viral hepatitis (B, C or B + C) or viral hepatitis alone
ISSN
1940-5901
Date Issued
2017-07-30
Author(s)
Abstract
Aim: Alcoholic liver disease and viral hepatitis are treated differently, making differential diagnosis essential. We aimed to determine whether platelet/spleen ratios can be used for differential diagnosis. Methods: This retrospective study enrolled 180 patients diagnosed with alcoholic (n=56) or viral liver disease (n=68) or combined alcoholic and viral liver disease (n=56) between 2009 and 2012. Patients without liver biopsy or complete data were excluded. Patients’ demographic and clinical data were collected, platelet/spleen ratios were determined. Data were compared between groups and associations between platelet/spleen ratios and alcoholic or viral liver disease were determined by univariate and ROC analysis. Results: Platelet/spleen ratios and liver function parameters were significantly different between groups (all P-values <0.05). Univariate analysis of platelet/spleen ratios compared between different groups revealed significant differences in platelet/spleen ratios between alcohol vs. combined group and viral vs. combined group but not between alcohol vs. viral group. Optimal cut-offs of platelet/spleen ratio to differentiate alcoholic liver disease and viral liver disease from combined alcoholic and viral liver disease were 2306 and 1650, respectively. Conclusion: Platelet/spleen ratio can only be used to differentiate alcoholic or viral liver disease from coexisting alcoholic and viral liver disease in conjunction with confirmation of viral hepatitis. © 2017, E-Century Publishing Corporation. All rights reserved.
Publisher
E-Century Publishing Corporation
Type
journal article