Detection of dural involvement by magnetic resonance imaging in adult patients with acute leukemias - preliminary experience
Journal
Annals of Hematology
Journal Volume
70
Journal Issue
5
Pages
243-249
Date Issued
1995
Author(s)
Abstract
Retrospectively, the dura in 18 adult patients with acute leukemia were evaluated by gadolinium-enhanced T1-weighted magnetic resonance imaging (MRI). Abnormal dural enhancements were detected in three of four patients with positive cerebrospinal fluid (CSF) cytology, in one of five with suspicious central nervous system (CNS) disease, and in two of nine asymptomatic patients. Computed tomography failed to demonstrate any dural abnormality in these six patients. The abnormal dural enhancement was found in either (a) the brain and the spine, (b) the thoracolumbar spine, or (c) the area adjacent to the parenchymal lesions. Three of the patients were in hematological remission stage; disappearance of the abnormal dural enhancement was observed 1-2 months after radiotherapy and high-dose systemic chemotherapy. The results suggest that MRI is a sensitive and noninvasive imaging modality and superior to CT in detecting dural disease in leukemic patients. ? 1995 Springer-Verlag.
SDGs
Other Subjects
antineoplastic agent; busulfan; cyclophosphamide; cytarabine; daunorubicin; doxorubicin; gadolinium; hydrocortisone; methotrexate; mitoxantrone; prednisolone; vincristine; acute leukemia; adult; aged; article; brain; brain disease; central nervous system disease; cerebrospinal fluid; computer assisted tomography; dura mater; female; human; intracerebroventricular drug administration; intrathecal drug administration; major clinical study; male; nuclear magnetic resonance imaging; parenchyma; priority journal; retrospective study; thoracolumbar spine; Adolescent; Adult; Aged; Brain; Dura Mater; Female; Human; Leukemia; Magnetic Resonance Imaging; Male; Retrospective Studies; Spinal Cord; Support, Non-U.S. Gov't
Type
journal article