Plumbagin induces the apoptosis of drug-resistant oral cancer in vitro and in vivo through ROS-mediated endoplasmic reticulum stress and mitochondrial dysfunction
Journal
Phytomedicine : international journal of phytotherapy and phytopharmacology
Journal Volume
111
Pages
154655
Date Issued
2023-03-01
Author(s)
Lin, Chien-Liang
Yu, Chung-I
Chuang, Jimmy Ming-Jung
Han, Kuang-Fen
Lin, Chang-Shen
Huang, Wan-Ping
Chen, Jeff Yi-Fu
Chen, Chung-Yi
Lin, Mei-Ying
Lee, Chien-Hsing
Abstract
Oral cancer is one of the leading causes of cancer-related deaths worldwide. Chemotherapy is widely used in the treatment of oral cancer, but its clinical efficacy is limited by drug resistance. Hence, novel compounds capable of overcoming drug-resistance are urgently needed.
Subjects
Drug-resistant oral cancer; Endoplasmic reticulum stress; Mitochondrial dysfunction; Plumbagin; Reactive oxygen species
SDGs
Publisher
NLM (Medline)
Type
journal article