DNA methyltransferase gene dDnmt2 and longevity of Drosophila
Resource
THE JOURNAL OF BIOLOGICAL CHEMISTRY
Vol. 280, No. 2, 861–864
Vol. 280, No. 2, 861–864
Journal
THE JOURNAL OF BIOLOGICAL CHEMISTRY
Vol. 280
Vol. 280
Journal Issue
No. 2
Pages
-
Date Issued
2005-01-14
Date
2005-01-14
Author(s)
Lin, M.J.
Tang, L.Y.
Reddy, M.N.
Shen, James C.K.
DOI
246246/2006111501221930
Abstract
The DNA methylation program of the fruit fly Drosophila
melanogaster is carried out by the single DNA
methyltransferase gene dDnmt2, the function of which
is unknown before. We present evidence that intactness
of the gene is required for maintenance of the normal
life span of the fruit flies. In contrast, overexpression of
dDnmt2 could extend Drosophila life span. The study
links the Drosophila DNA methylation program with the
small heatshock proteins and longevity/aging and has
interesting implication on the eukaryotic DNA methylation
programs in general.
Publisher
Taipei:National Taiwan University Dept Chem Engn
Type
journal article
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