Global perspective on the natural history of chronic hepatitis B: Role of hepatitis B virus genotypes A to J
Journal
Seminars in Liver Disease
Journal Volume
33
Journal Issue
2
Pages
97-102
Date Issued
2013
Author(s)
Abstract
Clinical outcomes of chronic hepatitis B virus (HBV) infection vary widely. In addition to host factors, several viral factors including HBV genotype, viral load, specific viral mutations and quantitative HBsAg levels, have been associated with disease outcomes. Among viral factors, HBV genotype correlates with not only the clinical outcomes, but also with the response to interferon treatment. Currently, 10 HBV genotypes have been identified. Compared with genotype A and B cases, patients with genotypes C and D have lower rates and usually delayed onset of spontaneous HBeAg seroconversion. HBV-genotype C has a higher frequency of basal core promoter (BCP) A1762T/G1764A mutation and preS deletion, and a higher viral load than genotype B. Similarly, genotype D has a higher prevalence of BCP A1762T/G1764A mutation than genotype A. These observations suggest pathogenic differences between HBV genotypes. Genotyping of HBV can help practicing physicians identify chronic hepatitis B patients at risk of disease progression. ? 2013 by Thieme Medical Publishers, Inc.
SDGs
Other Subjects
alanine aminotransferase; hepatitis B surface antigen; Africa; alanine aminotransferase blood level; alcohol consumption; chronicity; disease course; ethnic difference; Europe; family history; gene deletion; genotype; geographic distribution; hepatitis B; Hepatitis B virus; human; incidence; India; Japan; liver cell carcinoma; liver cirrhosis; liver fibrosis; prevalence; priority journal; review; seroconversion; Taiwan; United States; vaccination; vertical transmission; virus load; virus mutation; Animals; Antiviral Agents; Biological Markers; Carcinoma, Hepatocellular; Disease Progression; DNA, Viral; Drug Resistance, Viral; Genotype; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Liver Cirrhosis; Liver Neoplasms; Mutation; Phenotype; Treatment Outcome; Viral Load
Type
review