Overexpression of pituitary tumor-transforming gene-1 in hepatocellular carcinoma
Journal
Hepato-Gastroenterology
Journal Volume
53
Journal Issue
68
Pages
262-265
Date Issued
2006
Author(s)
Abstract
Background/Aims: Pituitary tumor-transforming gene-1, a recently identified proto-oncogene, was reported to be highly expressed in various tumors, such as tumors of the pituitary gland, adrenal gland, colon, ovary, endometrium, uterus, and kidney. The purpose of this study was to investigate the clinicopathologic significance of PTTG1 expression in hepatocellular carcinoma. Methodology: Expression of PTTG1 mRNA was evaluated by RT-PCR in 147 HCCs and 103 paired nontumorous liver tissues. Results: PTTG1 was found overexpressed in 80 of 147 (61%) HCCs. Overexpression of PTTG1 correlated with alpha-fetoprotein elevation (p<0.022) and higher tumor stage (stage IIIB-IV) tumors (p<0.009), but not with tumor grade, size, and survival. Conclusions: The results show that PTTG1 is overexpressed frequently in HCC, and correlated high stage tumors, indicating that overexpression of PTTG1 plays a role in the development and progression of HCC. ? H.G.E. Update Medical Publishing S.A.
Subjects
Hepatocellular carcinoma; Pituitary tumor-transforming gene-1
SDGs
Other Subjects
alpha fetoprotein; beta catenin; messenger RNA; protein p53; adolescent; adrenal tumor; adult; aged; article; cancer grading; cancer size; cancer staging; cancer survival; colon tumor; controlled study; correlation analysis; endometrium tumor; female; gene expression regulation; gene identification; gene overexpression; human; hypophysis tumor; kidney tumor; liver cell carcinoma; major clinical study; male; ovary tumor; pituitary tumor transforming gene 1; priority journal; proto oncogene; reverse transcription polymerase chain reaction; uterus tumor; Adolescent; Adult; Aged; Aged, 80 and over; beta Catenin; Carcinoma, Hepatocellular; Female; Genes, p53; Humans; Liver Neoplasms; Male; Middle Aged; Mutation; Neoplasm Proteins; Neoplasm Staging; RNA, Messenger
Type
journal article