Intracerebral Hemorrhage in Patients With CADASIL: Additive Impact of the R544C Variant and Hypertension?
Journal
Stroke
Journal Volume
56
Journal Issue
8
Start Page
2159
End Page
2166
ISSN
0039-2499
Date Issued
2025-08-01
Author(s)
Zhang, Ruiting
Tezenas Du Montcel, Sophie
Guey, Stéphanie
Hervé, Dominique
Chabriat, Hugues
Abstract
BACKGROUND: variants, and hypertension remain unclear. METHODS: We enrolled patients from 2 independent cohorts with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy in France (recruited since 2003) and Taiwan (recruited since 2019) and performed a cross-sectional retrospective analysis. Clinical history and evaluation were collected using standardized questionnaires and scales, while neuroimaging features were assessed with the CADA-MRIT inventory tool. Patients with and without a history of ICH were compared. Logistic regression and mediation analyses were conducted to identify factors associated with ICH. RESULTS: R544C variant on the occurrence of ICH would be explained by the effects of hypertension. CONCLUSIONS: R544C variant and hypertension appear to be independent risk factors for ICH in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy, with a potential additive effect. However, due to the study's cross-sectional design and population-specific factors, causality cannot be established. Prospective studies are thus needed to validate these findings and clarify underlying mechanisms.
Subjects
hypertension
magnetic resonance imaging
neuroimaging
risk factors
SDGs
Type
journal article