No evidence for linkage of long QT syndrome and chromosome 11p15.5 markers in a Chinese family: evidence for genetic heterogeneity
Journal
Human genetics
Journal Volume
94
Journal Issue
4
Pages
364
Date Issued
1994-10
Author(s)
Ko, Yu-Lin
Chen, Shih-Ann
Tang, Tang K.
Chiang, Chern-En
Chen, Jin-Jer
Teng, Ming-Sheng
Chang, Mau-Song
Lien, Wen-Pin
Wu, Cheng-Wen
Abstract
Recently the defective gene locus in seven Caucasian families with the Romano-Ward form of long QT syndrome (LQT) has been mapped to chromosome 11p. To understand the molecular basis of LQT in Chinese, a three-generation family was investigated. Fourteen family members were studied and five individuals were diagnosed to be affected, according to electrocardiographic criteria. Two genomic DNA probes (c-Ha-ras-3'-HVR and insulin-5'-HVR) and one tetranucleotide repeat polymorphism (THZ) derived from chromosome 11p15.5 loci and previously demonstrated to be closely linked to LQT were used as probes to analyze this family. A lod score of less than -2 was noted for all three polymorphisms. Our data show that there was no evidence of linkage between these three loci and the gene for LQT in this studied family. We believe that this result provides additional evidence for genetic heterogeneity of LQT.
Type
journal article