Arl4D-EB1 interaction promotes centrosomal recruitment of EB1 and microtubule growth
Journal
Molecular Biology of the Cell
Journal Volume
31
Journal Issue
21
Pages
2348-2362
Date Issued
2020
Author(s)
Abstract
The GTP-bound form of ADP-ribosylation factor-like 4D (Arl4D) small GTPase localizes to the centrosome and interacts with microtubule (MT) end-binding 1 (EB1) protein. Arl4D-EB1 interaction promotes EB1 centrosomal recruitment and increases the association of EB1 and p150 subunit of dynactin, thereby contributing to the nucleation of MTs at the centrosome.
SDGs
Publisher
American Society for Cell Biology
Type
journal article