Increased hyaluronan and CD44 expressions in intravenous leiomyomatosis
Journal
Acta Obstetricia et Gynecologica Scandinavica
Journal Volume
84
Journal Issue
4
Pages
322-328
Date Issued
2005
Author(s)
Abstract
Background. To determine the influence of hyaluronan and its receptor CD44 in the angiogenesis and invasiveness of intravenous leiomyomatosis (IVL). Methods. Paraffin-embedded sections from four IVL cases and 10 uterine leiomyoma cases were immunohistochemically stained for CD34, CD44, basic fibroblast growth factor (bFGF), vascular endothelial growth factor, and platelet-derived growth factor and assayed for microvessel densities. Hyaluronan was immunostained by biotinylated hyaluronan-binding peptide and the results were clinically correlated. Results. CD34 labeling showed significantly increased microvessel counts in IVL (156.6 ± 3.7), when compared to uterine leiomyomas (61.3 ± 27.3; P < 0.001). Hyaluronan and its receptor CD44 were prominently expressed in IVL when compared to leiomyomas and associated with an elevation in bFGF expression. Conclusions. IVL is a highly vascular neoplasm with elevated microvessel counts. The increase of hyaluronan and CD44 expression in IVL suggests that it is highly angiogenic and has an invasive potential. Elevation of hyaluronan may play a possible role in the pathogenesis of IVL. ? Acta Obstet Gynecol Scand 2005.
SDGs
Other Subjects
basic fibroblast growth factor; CD34 antigen; Hermes antigen; hyaluronic acid; platelet derived growth factor; vasculotropin; adult; angiogenesis; article; biotinylation; cancer invasion; clinical article; controlled study; human; human tissue; immunohistochemistry; intravenous leiomyomatosis; leiomyomatosis; microvasculature; priority journal; protein expression; Adult; Antigens, CD34; Antigens, CD44; Case-Control Studies; Female; Fibroblast Growth Factor 2; Humans; Hyaluronic Acid; Leiomyomatosis; Microcirculation; Middle Aged; Neovascularization, Pathologic; Platelet-Derived Growth Factor; Uterus; Vascular Endothelial Growth Factor A; Vascular Neoplasms