Isoprenoids from the soft coral Sarcophyton glaucum
Journal
Marine Drugs
Journal Volume
15
Journal Issue
7
Date Issued
2017
Author(s)
Abstract
Five new isoprenoids, 3,4,8,16-tetra-epi-lobocrasol (1), 1,15β-epoxy-deoxysarcophine (2), 3,4-dihydro-4α,7β,8α-trihydroxy-?2-sarcophine (3), ent-sarcophyolide E (4), and 16-deacetyl-halicrasterol B (5) and ten known compounds 6-15, were characterized from the marine soft coral Sarcophyton glaucum, collected off Taitung coastline. Their structures were defined by analyzing spectra data, especially 2D NMR and electronic circular dichroism (ECD). The structure of the known compound lobocrasol (7) was revised. Cytotoxicity potential of the isolated compounds was reported, too. ?2017 by the authors. Licensee MDPI.
Subjects
Ent-sarcophyolide E; Lobocrasol; Sarcophine; Sarcophyton glaucum
SDGs
Other Subjects
1,15beta epoxy deoxysarcophine; 16 deacetylhalicrasterol; 3,4 dihydro 4alpha hydroxy delta2 sarcophine; 3,4 dihydro 4alpha,7beta,8alpha trihydroxy delta2 sarcophine; 3,4 dihydro 4beta hydroxy delta2 sarcophine; 3,4,8,16 tetra epi lobocrasol; antineoplastic agent; ent sarcophyolide E; isoprenoid; klyflaccicembranol f; lobocrasol; loliolide; sarcoaldesterol B; sarcomilasterol; sarcophine; sarglaucsterol; srassumol A; unclassified drug; antineoplastic agent; terpene; Article; cancer cell; circular dichroism; coastal waters; concentration (parameters); coral; cytotoxicity; human; human cell; IC50; lung epithelium; MTT assay; nonhuman; nuclear magnetic resonance; Sarcophyton glaucum; Taiwan; animal; Anthozoa; chemistry; isolation and purification; nuclear magnetic resonance spectroscopy; tumor cell line; Animals; Anthozoa; Antineoplastic Agents; Cell Line, Tumor; Circular Dichroism; Humans; Magnetic Resonance Spectroscopy; Terpenes
Type
journal article