Parallel neural pathways mediate CO2 avoidance responses in Drosophila
Journal
Science
Journal Volume
340
Journal Issue
6138
Start Page
1338
End Page
1341
ISSN
368075
Date Issued
2013
Author(s)
Abstract
Different stimulus intensities elicit distinct perceptions, implying that input signals are either conveyed through an overlapping but distinct subpopulation of sensory neurons or channeled into divergent brain circuits according to intensity. In Drosophila, carbon dioxide (CO2) is detected by a single type of olfactory sensory neuron, but information is conveyed to higher brain centers through second-order projection neurons (PNs). Two distinct pathways, PNv-1 and PNv-2, are necessary and sufficient for avoidance responses to low and high CO2 concentrations, respectively. Whereas low concentrations activate PN v-1, high concentrations activate both PNvs and GABAergic PNv-3, which may inhibit PNv-1 pathway-mediated avoidance behavior. Channeling a sensory input into distinct neural pathways allows the perception of an odor to be further modulated by both stimulus intensity and context.
Publisher
American Association for the Advancement of Science
Type
journal article