The Tight Junction Protein ZO-1 Is Dispensable for Barrier Function but Critical for Effective Mucosal Repair
Journal
Gastroenterology
Journal Volume
161
Journal Issue
6
Pages
1924
Date Issued
2021
Author(s)
Zuo, Li
Odenwald, Matthew A
Madha, Shariq
Singh, Gurminder
Gurniak, Christine B
Abraham, Clara
Turner, Jerrold R
Abstract
Increased permeability is implicated in the pathogenesis of intestinal disease. In vitro and in vivo studies have linked down-regulation of the scaffolding protein ZO-1, encoded by the TJP1 gene, to increased tight junction permeability. This has not, however, been tested in vivo. Here, we assessed the contributions of ZO-1 to in vivo epithelial barrier function and mucosal homeostasis.
Subjects
Inflammatory Bowel Disease; Intestinal Permeability; Mitosis; Mitotic Spindle; Wnt
SDGs
Publisher
W B SAUNDERS CO-ELSEVIER INC
Type
journal article