Growth hormone cannot enhance the recovery of dexamethasone-induced osteopenia after withdrawal in young female wistar rats
Journal
Tohoku Journal of Experimental Medicine
Journal Volume
204
Journal Issue
4
Pages
257-266
Date Issued
2004
Author(s)
Abstract
Dexamethasone (DEX) suppresses the secretion of and responsiveness to growth hornone (GH). Here we aimed to assess the therapeutic effects of GH on the DEX-induced osteopenia. Female Wistar rats were treated for 2 weeks with DEX (200 μg/day) or saline as a control. DEX significantly decreased body weight gain, bone mineral density (BMD), growth plate thickness, area ratio of trabecular bone, and serum osteocalcin levels. DEX also elongated the tibia primary spongiosa and caused many tiny lipid droplets in the tibia marrow. These results indicated that DEX induced osteopenia in rats. We then assessed the effects of GH on the recovery of osteopenia after withdrawal of DEX. DEX-treated rats were subsequently treated for 1 week with GH (0.1 or 0.3 U/day) or saline, while saline-pretreated rats were treated for 1 week with saline as a control. GH (0.1 or 0.3 U/day)-treated rats showed a catch-up growth in various bone measurements by one week after DEX withdrawal, though most of them remained subnormal. GH treatment did not enhance the recovery of DEX-induced osteopenia. Therefore a short-term exposure to DEX significantly impaired the bone metabolism, which started to recover soon after withdrawal of DEX. Unfortunately, immediate administration of GH after withdrawal of DEX did not enhance the recovery process. ? 2004 Tokohu University Medical Press.
SDGs
Other Subjects
dexamethasone; human growth hormone; lipid; osteocalcin; sodium chloride; animal experiment; animal model; animal tissue; anthropometry; article; body weight disorder; bone density; bone disease; bone marrow; bone metabolism; bone mineral; bone turnover; catch up growth; controlled study; dose response; drug withdrawal; female; growth plate; histopathology; medical assessment; morphometrics; nonhuman; osteopenia; rat; thickness; tibia; trabecular bone; treatment failure; treatment outcome; weight gain; Animals; Bone and Bones; Bone Density; Bone Diseases, Metabolic; Dexamethasone; Female; Growth Hormone; Osteocalcin; Peptide Fragments; Procollagen; Random Allocation; Rats; Rats, Wistar
Type
journal article