Prevalence and the long-term coronary risks of patients with kawasaki disease in a general population <40 years: A national database study
Journal
Circulation: Cardiovascular Quality and Outcomes
Journal Volume
5
Journal Issue
4
Pages
566-570
Date Issued
2012
Author(s)
Abstract
Background-Patients with Kawasaki disease (kDa) may develop coronary arterial lesions and subsequent coronary events. The first reported case in Taiwan was in 1976, and the annual incidence from 2003 to 2006 was 69/100 000 children < 5 years. A population study from Taiwan, a country with a high incidence of kDa, national health insurance, and easily accessible medical care, would adequately reflect the long-term risk. Methods and Results-We retrieved the data of kDa patients from a national health insurance 2000 to 2010 database of Taiwan, a country with a child health index similar to those in the United States. The occurrence of coronary complications and interventions was identified by the respective International Classification of Diseases, Ninth Revision, codes. The prevalence of kDa in the population < 40 years was 34.9/100 000 (male/female ratio, 1.47). Coronary complications occurred in 1254 patients (5.37%; male/female ratio, 2.19), with an average annual risk of 2.4% (2.7% for males and 2.0% for females). An acute myocardial infarction occurred in 19 patients (0.08%; 18 males and 1 female), of whom one third were aged between 10 and 15 years (median, 15.7 years; range, 0.7-36.7 years). A coronary intervention was performed by catheterization in 18 patients (all males) at a median age of 24.5 years and by surgery in 10 patients (male/female ratio, 4.0) at a median age of 21.7 years, with mortality at discharge being 0% and 25%, respectively. Conclusions-This study estimated the overall prevalence of kDa (?1/2940) in a population < 40 years. They, particularly the males, carry long-term coronary risks from a young age. Risk stratification for a timely coronary intervention and risk modification are mandatory. ? 2012 American Heart Association, Inc.
SDGs
Other Subjects
acute heart infarction; adolescent; adult; age distribution; article; child; child health; coronary artery bypass graft; coronary artery disease; coronary artery surgery; coronary risk; female; groups by age; heart catheterization; human; incidence; International Classification of Diseases; long term care; major clinical study; male; mortality; mucocutaneous lymph node syndrome; national health insurance; percutaneous coronary intervention; prevalence; priority journal; school child; Taiwan; Adolescent; Adult; Age Factors; Angioplasty, Balloon, Coronary; Cardiac Catheterization; Child; Child, Preschool; Coronary Artery Bypass; Coronary Disease; Databases, Factual; Female; Humans; Infant; Male; Mucocutaneous Lymph Node Syndrome; Myocardial Infarction; Myocardial Ischemia; National Health Programs; Prevalence; Risk Assessment; Risk Factors; Sex Factors; Taiwan; Time Factors; Treatment Outcome; Young Adult
Type
journal article