An in-situ impedance-based whole blood anticoagulation diagnosis technology
Journal
ECS Transactions
Journal Volume
89
Journal Issue
6
Pages
73-80
Date Issued
2019
Author(s)
Abstract
The detection of anticoagulant dosage in blood is important and necessary in clinical operations. With high anticoagulant dosage, it results in heavy bleeding during surgery. With low anticoagulant dosage, in the opposite, it leads to clotting problem. To monitor the dosage, in traditional, optical-inspection instrumentations, such as PT (Prothrombin Time) and APTT (Activated Partial Thromboplastin Time), are commonly used in hospitals. However, the processes of PT and APTT measurements are complicated and time-consuming. To address these issues, in this work, electrical impedance analysis is employed to monitor the anticoagulant dosage in the whole blood samples obtained from rats. To optimize the impedance analysis, several electrode designs are implemented and examined. According to the experimental results, the more heparin adds, the larger slope value from the linear regression analysis can be extracted, and a good electrode configuration for blood coagulation measurement is tested with whole blood extracted from rats. ? The Electrochemical Society
Subjects
Diagnosis; Electric impedance; Electrodes; Photonics; Rats; Regression analysis; Activated partial thromboplastin time; Blood coagulation; Clinical operations; Diagnosis technology; Electrical impedance; Electrode configurations; Impedance analysis; Optical inspection; Blood
Type
conference paper