Brain stimulation improves cognitive control by modulating medial-frontal activity and preSMA-vmPFC functional connectivity
Journal
Human Brain Mapping
Journal Volume
36
Journal Issue
10
Start Page
4004
End Page
4015
ISSN
1065-9471
1097-0193
Date Issued
2015-10-01
Author(s)
DOI
10.1002/hbm.22893
Abstract
Previous research has demonstrated that brain stimulation can improve inhibitory control. However, the neural mechanisms underlying such artificially induced improvement remain unclear. In this study, by coupling anodal transcranial direct current stimulation (atDCS) with functional MRI, we found that atDCS over preSMA effectively improved stopping speed, which was associated with increased BOLD response in the preSMA and ventromedial prefrontal cortex (vmPFC). Furthermore, such atDCS-induced BOLD increase in vmPFC was positively correlated with participants' improvement in stopping efficiency, and the functional connectivity between preSMA and vmPFC increased during successful stop. These results suggest that the rapid behavioral improvement from preSMA brain stimulation involves modulated medial-frontal activity and preSMA-vmPFC functional connectivity.
Subjects
FMRI
PreSMA
Response inhibition
TDCS
VmPFC
Publisher
Wiley
Type
journal article