A mathematical framework for minimally invasive tumor ablation therapies
Journal
Critical Reviews in Biomedical Engineering
Journal Volume
42
Journal Issue
5
Pages
383-417
Date Issued
2014
Author(s)
Abstract
Minimally invasive tumor ablations (MITAs) are an increasingly important tool in the treatment of solid tumors across multiple organs. The problems experienced in modeling different types of MITAs are very similar, but the development of mathematical models is mostly performed in isolation according to modality. Fundamental research into the modeling of specific types of MITAs is indeed required, but to choose the optimal treatment for an individual the primary clinical requirement is to have reliable predictions for a range of MITAs.In this review of the mathematical modeling of MITAs 4 modalities are considered: radiofrequency ablation, microwave ablation, cryoablation, and irreversible electroporation. The similarities in the mathematical modeling of these treatments are highlighted, and the analysis of the models within a general framework is discussed. This will aid in developing a deeper understanding of the sensitivity of MITA models to physiological parameters and the impact of uncertainty on predictions of the ablation zone.Through robust validation and analysis of the models it will be possible to choose the best model for a given application. This is important because many different models exist with no objective comparison of their performance. The collection of relevant in vivo experimental data is also critical to parameterize such models accurately. This approach will be necessary to translate the field into clinical practice. ? 2014 by Begell House, Inc.
Subjects
Clinical research
Mathematical models
Physiological models
Tumors
Cryo ablations
Electroporation
Fundamental research
Mathematical frameworks
Microwave ablation
Minimally invasive
Physiological parameters
Radio-frequency Ablation
Ablation
Article
cell death
cryoablation
electric conductivity
electrode
electroporation
freezing
human
irreversible electroporation
mathematical model
microwave therapy
minimally invasive procedure
minimally invasive tumor ablation
nonhuman
priority journal
radiofrequency ablation
simulation
temperature dependence
thermal conductivity
tumor ablation
ablation therapy
algorithm
animal
Bovinae
image quality
liver
male
minimally invasive surgery
mouse
prostate
surgery
temperature
theoretical model
Ablation Techniques
Algorithms
Animals
Cattle
Humans
Liver
Male
Mice
Minimally Invasive Surgical Procedures
Models, Theoretical
Phantoms, Imaging
Prostate
Temperature
SDGs
Type
journal article