Quantification of cerebral blood capacity on patients with transient ischemic attack (TIA) using susceptibility-contrast perfusion-weighted MR imaging
Date Issued
2002-07-31
Date
2002-07-31
Author(s)
DOI
902213E002102
Abstract
The purpose of this one-year project is
to develop a series of image analysis methods
on clinical dynamic susceptibility-contrast
perfusion-weighted magnetic resonance (MR)
imaging to quantify the cerebrovascular
reserve capacity (CRC) during vasodilating
challenge task with acetazolamide (diamox).
The specific clinical target of the project is
transient ischemic attack (TIA), that is,
patients with symptoms of ischemic stroke
but recovered within 24 hours. Within one
fiscal year we have implemented the
deconvolution method based on the singular
value decomposition to derive cerebral blood
flow (CBF), from which the cerebrovascular
reserve capacity can be directly computed.
The CBF analysis algorithm widely used in
most international medical center has been
shown to exhibit significant prediction errors
dependent on tissue mean-transit-time (MTT),
which can vary substantially in pathological
conditions encountered in TIA patients. We
further proposed a method to remedy this
algorithm drawback to reduce the CBF
estimation error from the original +/-25% to
5%.
Subjects
perfusion
magnetic resonance
transient ischemic attack
absolute
quantification of cerebral blood flow
quantification of cerebral blood flow
singular value decomposition
cerebral
blood reserve capacity
blood reserve capacity
Publisher
臺北市：國立臺灣大學電機工程學系暨研究所
Type
report
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