A New Type of Intraocular Lens Based on Poly-para-xylylenes with Tunable Optical and Biofunctional Properties
Date Issued
2015
Date
2015
Author(s)
Wu, Jyun-Ting
Abstract
An innovative intraocular lens (IOL) device fabricated based on chemical vapor deposition encapsulation process by using functionalized poly-p-xylylenes is introduced herein. The advanced device provides non-compromised design parameters for both its optical and biological properties. As an excellent optical device, it provides a high refractive index that stems from intrinsic poly-p-xylylenes and a tunable effective focal length that is realized by manipulating the wetting properties of the encapsulated liquids; the device also offers protection from UV irradiation. As a key medical device, it exhibits excellent biocompatibility and reduced postoperative calcification through the intrinsic properties of poly-p-xylylenes after conducting alizarin red staining, scanning electron microscope, and energy dispersive X-ray spectroscopy examinations. In addition, these synergic functions, cell-adhering RGD peptide and anti-fouling poly(ethylene glycol) molecules, are provided with precise surface chemistry for location to a guided attachment or repellent properties for human lens epithelial cells, fibroblast cells, and human corneal epithelial cells, which is important in preventing device-associated complications.
Subjects
Biomaterail
Intraocular lens
Poly-p-xylylenes
Chemical vapor deposition
Tunable property
Type
thesis
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