社區停經初期婦女骨質流失及危險因子之追蹤研究(第一年)
Date Issued
2003
Date
2003
Author(s)
�Y�s�S
DOI
912314B002387
Abstract
Osteoporosis is a major public health concern of the 21st century due to the rapidly increasing elderly population worldwide. Women especially will lose bone rapidly after the menopause, which can lead to osteopenia initially, with worsening to osteoporosis and an increased propensity to fracture. Statistics from the USA show approximately 1.5 million fractures occurring each year as a consequence of osteoporosis. The steep increase in the elderly population of Taiwan in recent decades, similar to Western developed nations, will further emphasize the urgency of preventative strategy against osteoporosis.
Although there have been studies on the bone mineral density (BMD) of Taiwanese women, these studies, however, were mainly cross-sectional in nature. In order to investigate reproductive and lifestyle risk factors or protective factors for bone loss in the postmenopausal years and avoid the shortcomings of a cross-sectional study design, this longitudinal community-based cohort study with a 2-year follow-up were carried out. We include 280 postmenopausal women as study subjects in the first year.
Using a questionnaire, baseline characteristics (age, years of education, etc.), lifestyle
characteristics (ever smoked, drink alcohol, physical activity level, etc.), reproductive
history (age at menarche and menopause, parity and number of livebirths, breastfeeding, etc.), as well as pertinent medical and family history were recorded. Anthropometric measurements were taken of each subject (height, weight, BMI, waist-hip ratio (WHR), etc.). Every subject received dual energy X-ray absorptiometry (DEXA)
measurements of BMD ( bone mineral density) for the lumbar spine and left hip and total body fat distribution. Urine sampling and blood drawing were done to test the bone turnover marker deoxypyridinoline (Dpd).
The data collected during the first year here will be used as baseline to compare with any weight, height, lifestyle and BMD changes 1 and 2 years later.
Part of these original data were shown in appendix. The only problem we encounter during the first - year study is SARS episode, which hindered subjects from receiving DEXA exam at hospital. Hence the subject number enrolled is less than planned.
Subjects
bone mineral density (BMD)
menopause
cohort study
risk factor
SDGs
Publisher
臺北市：國立臺灣大學醫學院一般醫學科
Type
journal article
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