On-substrate fabrication of a bio-conjugated Au nanoring solution for photothermal therapy application
Journal
Nanotechnology
Journal Volume
24
Journal Issue
6
Date Issued
2013
Author(s)
Tseng, H.-Y.
Chen, W.-F.
Chu, C.-K.
Chang, W.-Y.
Kuo, Y.
Kiang, Y.-W.
Abstract
The on-substrate fabrication of a bio-conjugated Au nanoring (NRI) solution with the localized surface plasmon (LSP) resonance wavelength in the 1200-1300 nm range is demonstrated. Also, the effects of photothermal therapy through LSP resonance-induced absorption enhancement are illustrated by applying the bio-conjugated Au NRIs to human liver cancer cells and illuminating the cells with a laser of 1315 nm in wavelength. The Au NRI fabrication is based on the techniques of nano-imprint lithography and metal secondary sputtering. The procedure for on-substrate surface modification of Au NRIs leads to a high production yield of bio-conjugated NRIs. The threshold levels of the local laser intensity for injuring cancer cells based on the LSP resonances of Au NRIs of two different samples are determined. ? 2013 IOP Publishing Ltd.
SDGs
Other Subjects
Absorption enhancement; Au nanoring; Cancer cells; Human liver cancer cells; Laser intensities; Localized surface plasmon; Photothermal therapy; Production yield; Resonance wavelengths; Threshold levels; Cells; Lasers; Nanoimprint lithography; Nanorings; Nanostructured materials; Resonance; Fabrication; gold; nanomaterial; article; cell strain HepG2; chemistry; human; hyperthermic therapy; liver; liver tumor; methodology; nanotechnology; pathology; phototherapy; solution and solubility; surface plasmon resonance; Gold; Hep G2 Cells; Humans; Hyperthermia, Induced; Liver; Liver Neoplasms; Nanostructures; Nanotechnology; Phototherapy; Solutions; Surface Plasmon Resonance
Type
journal article