A double-blind, randomized, placebo-controlled study to evaluate the efficacy and safety of STA-2 (Green tea polyphenols) in patients with chronic stable angina
Journal
Acta Cardiologica Sinica
Journal Volume
32
Journal Issue
4
Pages
439-449
Date Issued
2016
Author(s)
Abstract
Background: Green tea intake has been shown to improve endurance capacity in animal studies, but whether it has a similar effect on humans remains unclear. A randomized, double-blinded, parallel-controlled study was conducted to evaluate the short-term effect of STA-2, a pharmaceutical preparation of green tea polyphenols, in patients with effort-induced angina and documented positive exercise tolerance test. Methods: A total of 79 patients recruited from three medical centers were randomly assigned to receive 2 STA-2 250 mg capsules, each containing 100 mg green tea polyphenols, three times daily, or placebo for six weeks after two consecutive symptom-limited treadmill exercise tests to ascertain the reproducibility of exercise tolerance. Results: There was no difference in total exercise tolerance time frombaseline toWeek 6 between two groups (p = 0.639). There were also no observed improvements in subgroup analyses stratified by age, gender, and BMI categories. However, a significant reduction in low-density lipoprotein levels was shown in patients in the STA-2 group (-8.99 ± 19.18 mg/dL) versus the placebo group (0.57 ± 19.77 mg/dL), p = 0.037, with greater benefits in patients not taking antihyperlipidemic drugs (STA-2: -9.10 ± 19.96 mg/dL vs. placebo: 4.42 ± 15.08 mg/dL, p = 0.037). Conclusions: STA-2 treatment for 6 weeks did not increase exercise time asmeasured on a treadmill. However, this study also indicated that STA-2 treatment could have potential beneficial effects on LDL-cholesterol concentrations. ? 2016, Republic of China Society of Cardiology. All rights reserved.
Subjects
Chronic stable angina; Coronary disease; Green tea polyphenols; Ischemia; Low density lipoprotein (LDL)
SDGs
Other Subjects
9,11 epithio 11,12 methanothromboxane A2; C reactive protein; green tea extract; lactate dehydrogenase; low density lipoprotein; placebo; plasminogen; polyphenol derivative; adult; antioxidant activity; Article; body mass; Camellia sinensis; controlled study; double blind procedure; drug efficacy; drug safety; electrocardiography; exercise tolerance; female; high performance liquid chromatography; human; major clinical study; male; middle aged; multicenter study; oxidative stress; randomized controlled trial; stable angina pectoris; tea; thin layer chromatography; treadmill exercise
Publisher
Republic of China Society of Cardiology
Type
journal article