Multi-ethnic Imputation System (MI-System): A genotype imputation server for high-dimensional data
Journal
Journal of biomedical informatics
Journal Volume
143
Date Issued
2023-06-10
Author(s)
Lee, Chien-Yueh
Shen, Ying-Cheng
Lu, Kuan-Chen
Hsiao, Tzu-Hung
Lin, Ching-Heng
Tsai, Mong-Hsun
Abstract
Genotype imputation is a commonly used technique that infers un-typed variants into a study's genotype data, allowing better identification of causal variants in disease studies. However, due to overrepresentation of Caucasian studies, there's a lack of understanding of genetic basis of health-outcomes in other ethnic populations. Therefore, facilitating imputation of missing key-predictor-variants that can potentially improve a risk health-outcome prediction model, specifically for Asian ancestry, is of utmost relevance.
Subjects
Beagle5.1; Genotype imputation; IMPUTE2; IMPUTE5; Taiwan biobank; Web-server
Type
journal article