Predicting FDG-PET Images From Multi-Contrast MRI Using Deep Learning in Patients With Brain Neoplasms
Journal
Journal of Magnetic Resonance Imaging
Journal Volume
59
Journal Volume
59
Journal Issue
3
Journal Issue
3
Start Page
1010
End Page
1020
ISSN
10531807
Date Issued
2024-03
Author(s)
Ouyang, Jiahong
Duarte Armindo, Rui
Davidzon, Guido Alejandro
Hawk, Kristina Elizabeth
Moradi, Farshad
Rosenberg, Jarrett
Lan, Ella
Zhang, Helena
Zaharchuk, Greg
Abstract
Background: 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) is valuable for determining presence of viable tumor, but is limited by geographical restrictions, radiation exposure, and high cost. Purpose: To generate diagnostic-quality PET equivalent imaging for patients with brain neoplasms by deep learning with multi-contrast MRI. Study Type: Retrospective. Subjects: Patients (59 studies from 51 subjects; age 56 ± 13 years; 29 males) who underwent 18F-FDG PET and MRI for determining recurrent brain tumor. Field Strength/Sequence: 3T; 3D GRE T1, 3D GRE T1c, 3D FSE T2-FLAIR, and 3D FSE ASL, 18F-FDG PET imaging. Assessment: Convolutional neural networks were trained using four MRIs as inputs and acquired FDG PET images as output. The agreement between the acquired and synthesized PET was evaluated by quality metrics and Bland–Altman plots for standardized uptake value ratio. Three physicians scored image quality on a 5-point scale, with score ≥3 as high-quality. They assessed the lesions on a 5-point scale, which was binarized to analyze diagnostic consistency of the synthesized PET compared to the acquired PET. Statistical Tests: The agreement in ratings between the acquired and synthesized PET were tested with Gwet's AC and exact Bowker test of symmetry. Agreement of the readers was assessed by Gwet's AC. P = 0.05 was used as the cutoff for statistical significance. Results: The synthesized PET visually resembled the acquired PET and showed significant improvement in quality metrics (+21.7% on PSNR, +22.2% on SSIM, −31.8% on RSME) compared with ASL. A total of 49.7% of the synthesized PET were considered as high-quality compared to 73.4% of the acquired PET which was statistically significant, but with distinct variability between readers. For the positive/negative lesion assessment, the synthesized PET had an accuracy of 87% but had a tendency to overcall. Conclusion: The proposed deep learning model has the potential of synthesizing diagnostic quality FDG PET images without the use of radiotracers. Evidence Level: 3. Technical Efficacy: Stage 2.
Subjects
brain neoplasm
deep learning
FDG PET imaging
PET-MR
SDGs
Publisher
John Wiley and Sons Inc
Type
journal article