The potential of serum levels of soluble tumour necrosis factor receptor I as a biochemical marker in cervical cancer
Journal
BJOG: An International Journal of Obstetrics and Gynaecology
Journal Volume
104
Journal Issue
11
Pages
1314-1319
Date Issued
1997
Author(s)
Abstract
Objectives To investigate the significance of serum levels of soluble tumour necrosis factor receptor I (sTNF-RI) as a potential biochemical marker in women with cervical cancer. Design A prospective, case-controlled study. Participants Seventy-one women with cervical cancer and 33 women with myoma were enrolled in this study. Methods Pre-operative serum levels of sTNF-RI were measured with a standard enzyme-linked immunosorbent assay utilising murine monoclonal antibody against sTNF-RI. Main outcome measures All data in both groups were evaluated and correlated with the pre-operative serum levels of sTNF-RI. Data analysis was carried out using ANOVA with multiple comparison and linear regression. Results The mean serum level of sTNF-RI in the cervical cancer group was significantly lower than that in the myoma group (P < 0.001). The sTNF-RI levels decreased sequentially with disease progression from Stage Ia to IIb in women with cervical cancer. The mean serum level of sTNF-RI was also significantly lower in women with positive lymph node (P < 0.05) or recurrent cancer (P < 0.001). A negative correlation was observed between serum levels of sTNF-RI and tumour size (r=?0.622, P < 0.0001). Conclusions Decreased pre-operative serum levels of sTNF-RI are observed in women with cervical cancer. The results do not support that the use of sTNF-RI as a biochemical marker for cervical cancer. ? 1997 Wiley. All rights reserved.
SDGs
Other Subjects
biochemical marker; tumor necrosis factor receptor; adult; article; blood level; cancer recurrence; controlled study; enzyme linked immunosorbent assay; female; human; major clinical study; priority journal; uterine cervix cancer; Adult; Case-Control Studies; Enzyme-Linked Immunosorbent Assay; Female; Humans; Leiomyoma; Middle Aged; Prospective Studies; Receptors, Tumor Necrosis Factor; Tumor Markers, Biological; Uterine Cervical Neoplasms; Uterine Neoplasms
Type
journal article