ASSOCIATION OF AFLATOXIN B-1-ALBUMIN ADDUCT LEVELS WITH HEPATITIS B SURFACE ANTIGEN STATUS AMONG ADOLESCENTS IN TAIWAN
Resource
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION v.10 n.11 pp.1223-1226
Journal
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
Journal Volume
v.10
Journal Issue
n.11
Pages
1223-1226
Date Issued
2001
Date
2001
Author(s)
CHEN, SHU-YUAN
CHEN, CHIEN-JEN
CHOU, SHAN-RU
HSIEH, LING-LING
Abstract
Chronic hepatitis B virus (HBV) infection and aflatoxin B-1(
AFB(1)) exposure interact synergetically to induce
hepatocellular carcinoma. One suggested mechanism for this
interaction is the enhanced activation of AFB(1) in
chronically HBV-infected individuals. Whereas no
associations between chronic HBV infection and AFB(1)-
albumin adducts were observed in several studies in adults,
hepatitis B surface antigen (HbsAg)-positive children were
found to have elevated adducts in Gambia. To assess the
association between chronic HBV infection and AFB(1)-albumin
adduct level in Taiwan, 200 junior high school adolescents
from 20 townships were assayed for HBsAg and AFB(1)-albumin
adducts. The mean AFB(1)-albumin adduct level was higher in
HBsAg-positive compared with HBsAg-negative subjects. The
association between HBsAg status and AFB(1)-albumin adducts
remained after multivariate adjustment. This finding
additionally supports the synergetic interaction between HBV
and AFB(1), but the mechanism remains to be elucidated.
Subjects
REPUBLIC-OF-CHINA
HEPATOCELLULAR-CARCINOMA
VIRUS-INFECTION
CHEMICAL HEPATOCARCINOGENS
METABOLIC-ACTIVATION
TRANSGENIC MICE
SDGs
Type
journal article