Research of environmental sensitive magnetic nanoparticles preparation and drug release behavior I.Synthesis of hollow magnetic particles by emulsifier-free emulsion polymerization II.Synthesis of self-assembly nanoparticles by living radical polymerization
Date Issued
2011
Date
2011
Author(s)
Wang, Yu-Cheng
Abstract
In this study, stimuli responsive latex nanoparticles composed of copolymers of N-isoprylacrylamide(NIPAAm) and acrylic acid(AA) derivatives were synthesized by two methods. Because of the thermo-sensitivity of polyNIPAAm and the pH-sensitivity of polyAA derivatives, these nanoparticles which is sensitive to both temperature and pH can be used in drug release system as a drug carrier.
In the first method, emulsifier-free emulsion polymerization were used to synthesize magnetic hollow particles composed of random copolymer of NIPAAm and methacrylic acid(MAA) . Particle morphology. drug loading and release behavior were discussed. The magnetic hollow particles which can respond to temperature and pH were synthesized successful. The largest drug release percentage was found in the condition of room temperature and basic system. The drug bust phenomena occurred when particles were put into acidic solution.
In the second method, well-defined living block copolymer of PNIPAAm and PAA was synthesized by Reversible Addition-Fragmentation Ttransfer (RAFT) to achieve self-assembly behavior at high temperature. When the poly(NIPAAm-b-AA) aqueous solution was heated, various morphologies in different ratios of PNIPAAm and PAA were observed due to the hydrophobic nature of PNIPAAm above its LCST. Sensitivities of temperature and pH were also confirmed in the lowest critical solution temperature experiment.
Subjects
polyNIPAAm
polyAA derivatives
Living polymerization
drug release behavior
self-assembly behavior
Type
thesis
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