Incidence of atrial fibrillation in a population with impaired glucose tolerance: The contribution of glucose metabolism and other risk factors. A post hoc analysis of the Nateglinide and Valsartan in Impaired Glucose Tolerance Outcomes Research trial
Resource
Am. Heart J., 166(5), 935-+
Journal
American Heart Journal
Pages
935-940.e1
Date Issued
2013
Date
2013
Author(s)
Latini, Roberto
Staszewsky, Lidia
Sun, Jie-Lena
Bethel, M. Angelyn
Disertori, Marcello
Haffner, Steven M.
Holman, Rury R.
Chang, Futien
Giles, Thomas D.
Maggioni, Aldo P.
Rutten, Guy E. H. M.
Standl, Eberhard
Thomas, Laine
Tognoni, Gianni
Califf, Robert M.
McMurray, John J. V.
Abstract
Background The role of dysglycemia as an additional risk factor for atrial fibrillation (AF) is controversial. Therefore, it was of interest to assess risk factors for incident AF in a large, representative population of patients with cardiovascular risk factors and impaired glucose tolerance but not overt diabetes in NAVIGATOR.
Methods Predictors of incident AF were analyzed in 8,943 patients without AF at baseline by Cox proportional hazards regression. Study treatments (valsartan vs no valsartan and nateglinide vs no nateglinide) and the time-dependent covariate for progression to type 2 diabetes mellitus were added separately to the model.
Results The median age of the 8,943 patients included in the present analysis of the NAVIGATOR trial was 63 years. Half of those patients were men, 6,922 (77.4%) had a history of hypertension, and 255 (2.9%) had heart failure. The median glycated hemoglobin was 6%. During the study, 613 of the 8,943 patients without AF at baseline presented with at least 1 episode of AF (6.9% 5-year incidence). Besides established predictors of incident AF, a 1 mmol/ L increment of baseline fasting glucose, but not progression to diabetes, was found to be associated with a 33% increased risk of incident AF. Neither valsartan nor nateglinide affected AF incidence.
Conclusions In a trial population with impaired glucose tolerance, fasting plasma glucose and well-known risk factors (age, hypertension, and elevated body weight), but not progression to diabetes, predict risk of AF.
SDGs
Other Subjects
glucose; glycosylated hemoglobin; nateglinide; valsartan; adult; article; body weight; cardiovascular risk; diet restriction; disease course; female; glucose blood level; glucose metabolism; heart atrium fibrillation; heart failure; human; hypertension; impaired glucose tolerance; incidence; major clinical study; male; non insulin dependent diabetes mellitus; outcomes research; post hoc analysis; priority journal; risk factor
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