行政院國家科學委員會專題研究計畫成果報告:以T淋巴球廓清法預防異體肢體移植後移植物-宿主病之研究
Date Issued
1999
Date
1999
Author(s)
葉力森
DOI
882313B002081
Abstract
Limb allotransplantation is a combination of composite tissues including a great number of highly antigenic and immunocompetent tissues. In animal model study, limb grafts usually encounter uncontrollable rejection and other complications including graft-versus-host
disease (GVHD). In our recent studies the rejection of limb grafts may be successfully controlled by combination of novel immuno suppression agents with less side- effects. In this study, limb composite tissue allotransplantation is carried out with a combination of immunosuppressants , bone marrow transplantation, and chemo T cell depletion agents. As a result, this model did not develop a reliable GVHD model, however, some animals developed tolerance after stopping immunosuppressants when the agents were with enough dosage. Under the condition of underdose immunosuppression, no microchimerism was accomplished, and the bone marrow cells may lead to early rejection even GVHD. A further refined immunosuppression protocol is mandatory in future composite tissue trnasplantation.
Subjects
Limb allotransplantation
Graft- versus-host disease(GVHD)
Monoclonal
antibody(mAb)
antibody(mAb)
T cell depletion
Publisher
臺北市：國立臺灣大學獸醫學系暨研究所
Type
report
File(s)![Thumbnail Image]()
Loading...
Name
882313B002081.pdf
Size
69.25 KB
Format
Adobe PDF
Checksum
(MD5):d442a50586a89a7699769db477828edc