18-Fluoro-2-Deoxyglucose Positron Emission Tomography in Detecting Residual/Recurrent Nasopharyngeal Carcinomas and Comparison with Magnetic Resonance Imaging
Resource
CANCER v.98 n.2 pp.283-287
Journal
CANCER
Journal Volume
v.98
Journal Issue
n.2
Pages
283-287
Date Issued
2003
Date
2003
Author(s)
YEN, RUOH-FANG
HONG, RUEY-LONG
PAN, MEI-HSIU
WANG, YAO-HONG
HUANG, KOU-MOU
Abstract
BACKGROUND. It is known that 18-fluoro-2-deoxyglucose positron emission tomography (FDG-PET) is effective in the early detection of residual/ recurrent nasopharyngeal carcinomas (NPC). To compare FDG-PET with the conventional magnetic resonance imaging (MRI) for the detection of residual/recurrent NPC, the authors studied 67 follow-up cases of patients with NPC using both FDG-PET and MRI. METHODS. From February 1997 to February 2001, 67 NPC patients (14 women, 53 men; age range, 16-67 years; mean age , 46.6 +/- 12.5 years) were recruited. Both FDG-PET and MRI of the head and neck area for each patient were performed at least 4 months ( duration range, 4-70 months; mean, 14 +/- 13.5 months) after radiotherapy or radiotherapy with concurrent chemotherapy. The final diagnosis was confirmed by biopsy or clinical follow-up for at least 6 months. RESULTS. The sensitivity, specificity, accuracy, positive predictive value (PPV), and negative predictive value (NPV) of FDG-PET images were 100%, 93.4%, 95 .5%, 87.5%, and 100%, respectively. In contrast, the sensitivity, specificity, accuracy, PPV, and NPV of the MRI scans were 61.9%, 43.5%, 49 .3%, 33.3%, and 70.0%, respectively. CONCLUSIONS. The results of the current study suggest that FDG-PET is much more effective than MRI in detecting residual/recurrent NPC. (C) 2003 American Cancer Society.
Subjects
SQUAMOUS-CELL CARCINOMA
COMBINED PET/CT SCANNER
CONCOMITANT RADIOTHERAPY
F-18 FLUORODEOXYGLUCOSE
HIGH ACCUMULATION
TUMOR RECURRENCE
SDGs