The Association Study among Health Disorders, Emotion and Handedness
Date Issued
2008
Date
2008
Author(s)
Lu, Hui-Chun
Abstract
The contribution of genetics in human handedness has been supported by many studies. One postulation is that a asymmetry gene is critical in the process of cerebral lateralization and the evolution of handedness. Handedness and scalp hair-whorl direction may develop from a common genetic mechanism also affects cerebral lateralization. This cerebral lateralization may also influence immune responses, emotional processes and affective disorders. So the handedness may be regarded as a phenotypical feature of functional cerebral lateralization.he questionnaire study was designed to compare the left-handed families, hair-whorl direction, diseases(medical history and self assessment), and emotional states among handedness group. The structural questionnaire included personnel data, the revised Edinburgh Handedness Inventory, and the Taiwanese adaptation of the Depression Anxiety Stress Scales (DASS). he questionnaire was completed by 208 subjects. There are no differences of personnel data include age, sex, ethnic origin, education and occupation, among handedness group. Handedness was determined by self-report revised Edinburgh Handedness Inventory. Three discrete hand-preference clusters were identified, i.e. right-, mixed- and left-handed group. The DASS is a 42-item self-report instrument to measure the three related negative emotional states of depression, anxiety and tension/stress.owever, we found no association between handedness and hair-whorl direction, and immune diseases, but only that handedness had a family cluster phenomenon. The findings indirectly support the genetic influence on human handedness. The depression, anxiety and stress mean scores in left-handed group are all higher than other two groups, but these differences are not significant. o address the hypothesis that degree of cerebral lateralization may be a mediating mechanism of handedness, immunity and emotion status, the empirical findings on this issue are often inconsistent. A large-scale study and integration various disciplines in the search for a comprehensive mechanism of handedness and cerebral lateralization should be considered.
Subjects
Handedness
cerebral lateralization
Edinburgh Handedness Inventory
DASS
Immune
Hair-whorl direction
SDGs
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