Postchallenge hyperglycaemic spike associate with arterial stiffness
Journal
International Journal of Clinical Practice
Journal Volume
61
Journal Issue
3
Pages
397-402
Date Issued
2007-03
Author(s)
Huang C.-L.
Wang W.-L.
Feng M.-H.
Liau C.-S.
Hwang B.-S.
Lee Y.-T.
Abstract
Several large-scale epidemiological and intervention studies strongly indicate that postchallenge hyperglycaemia is the main factor associated with increasing the risk of morbidity and mortality in type 2 diabetes. However, the mechanisms that increase the risk of cardiovascular disease remain unclear. We aimed to study the relationship between postchallenge hyperglycaemia and arterial stiffness. We recruited 40 healthy subjects from a physical examination in 2005. Cardio-ankle vascular index (CAVI) was automatically calculated by VaSera VS-1000. For the reliability study, we performed the baseline study in the first 20 subjects who were returned to receive repeated measurements of CAVI 2 weeks later. The determinants of mean CAVI at different timings of oral glucose tolerance test (OGTT) study were analysed by constructing multivariate linear regression models. In reliability test, the inter-observer correlation coefficient was 0.82 for right CAVI, 0.87 for left CAVI and 0.85 for mean CAVI. Age, systolic blood pressure (SBP), diastolic blood pressure (DBP), glucose levels at 60 min (Glu60) and glucose area under the curve of OGTT (GluAUC) are found to be significantly and positively correlated to right CAVI, left CAVI and mean CAVI (p < 0.05). After adjustment for age, gender and SBP, Glu60 and GluAUC are still independent determinants of CAVI. In subjects without clinical diagnosis of type 2 diabetes, postchallenge hyperglycaemic spike is highly associated with CAVI, a good parameter of aortic stiffness, independent of age, gender and blood pressure. ? 2007 The Authors Journal compilation 2007 Blackwell Publishing Ltd.
Subjects
Arterial stiffness; Cardio-ankle vascular index; Diabetes mellitus; Postchallenge hyperglycaemic spike; Pulse wave velocity
SDGs
Other Subjects
glucose; adult; age distribution; analytical parameters; area under the curve; artery compliance; article; cardioankle vascular index; controlled study; correlation analysis; correlation coefficient; diastolic blood pressure; diet restriction; disease association; exercise; female; glucose blood level; human; human experiment; hyperglycemia; male; measurement; multiple linear regression analysis; observer variation; oral glucose tolerance test; priority journal; reliability; repeat procedure; rigidity; scoring system; statistical significance; systolic blood pressure; Adult; Arteries; Blood Glucose; Blood Pressure; Compliance; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Female; Glucose Tolerance Test; Humans; Hyperglycemia; Male; Middle Aged; Regression Analysis; Reproducibility of Results; Risk Factors; Vascular Resistance
Type
journal article